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pentobarbital decreases levels of toremifene by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. CYP3A4 inducers boost charge of toremifene metabolism, lowering the constant-state concentration in serum.pentobarbital will reduce the extent or result of brexpiprazole by influencing hepatic/intestinal enzyme CYP3A4 m